The EU hit Google with the record fine - which broke the previous EU record for a monopoly case, against USA chipmaker Intel of 1.06 billion euros in 2009 - in June for illegally favoring its shopping service in search results.
Lodging the appeal does not suspend the fine, meaning Google is still obliged to pay up, though it can put the money in a blocked account until the decision is reached.
Murray, Hingis win mixed doubles title at US Open
I think it happened six or seven tournaments in a row that we lost to the team that went on and won. Open girls' champion on Sunday when she faces fellow American Amanda Anisimova.
However, setting up a court battle between Brussels and the internet giant could take years to resolve and make already tense relations between Europe and the USA tech giant even more fraught, AFP reported.
European Union competition commissioner Margrethe Vestager is investigating Google in three cases, as well as tech giants Apple, Facebook and Qualcomm.
Google is now set for a legal showdown in Brussels that could take years to resolve, and add further strain on already tense relations between the company and the EU.
Kohli fires India to seven-wicket T20 win
When India were 2 down, Sri Lanka were right back in the game with scoring rate being brought down and new batsmen at the crease. The focus of the lone T20I was whether India would be able to complete a 9-0 thrashing of Sri Lanka across formats.
The EU fined the internet giant for abusing its dominance in Europe to position its own shopping comparison service at the top of Google search results. That order came with a 2.4 billion euro ($2.9 billion) fine, more than double the 1.06 billion euros for Intel.
The EU is also investigating whether Google tried to squeeze out its rivals in online search advertising and through its Android mobile operating system.
Kerala will eat beef, no food emergency in India, says KJ Alphons
The new inductions include four former civil servants with the 1979 batch, Kerala cadre officer being one of them. He resigned from Indian Administrative Service to contest in 2006 Kerala Assembly elections.